Dosing study of esmolol for reducing hemodynamic changes during lightwand intubationDosing study of esmolol for reducing hemodynamic changes during lightwand intubation
- Other Titles
- Dosing study of esmolol for reducing hemodynamic changes during lightwand intubation
- Authors
- Kang Jin Ku; Yoo Sie Hyeon; 정진헌; Kim Nan Seol; 정호순; 서용한; Chun Hea Rim; 공형윤; Son Hee Dong; Kim A Joo
- Issue Date
- 2020
- Publisher
- 대한마취통증의학회
- Keywords
- Blood pressure; Esmolol; Heart rate; Intubation; Lightwand; Rate pressure product.
- Citation
- Anesthesia and Pain Medicine, v.15, no.4, pp 417 - 423
- Pages
- 7
- Journal Title
- Anesthesia and Pain Medicine
- Volume
- 15
- Number
- 4
- Start Page
- 417
- End Page
- 423
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3389
- DOI
- 10.17085/apm.19067
- ISSN
- 1975-5171
2383-7977
- Abstract
- Background: Lightwand is a convenient tool that can be used instead of a laryngoscope for intubation. Tracheal intubation causes direct stimulation of the larynx, drastically increasing hemodynamic values including blood pressure and heart rate. This study aims to identify the effect of different doses of esmolol on hemodynamic changes during lightwand intubation.Methods: The study subjects included 140 patients who underwent general anesthesia for elective surgery. The patients were randomly divided into four groups (35 patients in each group). The ‘C’ group only received 20 ml of normal saline, while the ‘E0.5’, ‘E1’, and ‘E2’ groups received 20 ml of normal saline containing esmolol—0.5 mg/kg, 1 mg/kg, and 2 mg/kg, respectively, injected 2 min prior to intubation. The patients’ blood pressure, heart rate, and rate-pressure product were measured six times, before and after the intubation.Results: The degree of heart rate elevation was suppressed in the E1 and E2 groups compared to the C group, and RPP after intubation significantly decreased in the E2 group compared to the C group.Conclusions: 1–2 mg/kg of a single esmolol injection prior to lightwand intubation effectively blunts heart rate elevation, and 2 mg/kg of esmolol injection blunts rate-pressure product elevation.
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Collections - College of Medicine > Department of Anesthesiology > 1. Journal Articles
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