A comparison study on efficacy, insulin sensitivity and safety of Glimepiride/Metformin fixed dose combination versus glimepiride single therapy on type 2 diabetes mellitus patients with basal insulin therapy
- Authors
- Yu, Hea Min; Kim, Sang Jin; Chun, Sung Wan; Park, Keun Young; Lim, Dong Mee; Lee, Jong Min; Hong, Jun Hwa; Park, Kang Seo
- Issue Date
- Sep-2019
- Publisher
- Elsevier BV
- Keywords
- Type 2 diabetes mellitus; Sulfonylurea compounds; Metformin
- Citation
- Diabetes Research and Clinical Practice, v.155
- Journal Title
- Diabetes Research and Clinical Practice
- Volume
- 155
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4245
- DOI
- 10.1016/j.diabres.2019.107796
- ISSN
- 0168-8227
1872-8227
- Abstract
- Aim: The aim of this study was to analyze the efficacy, insulin sensitivity and safety in the event of administering sulfonylurea-based drugs and metformin in combination with basal insulin. Methods: A randomized, open-label, parallel, 16-week trial was conducted across four study centers. The 97 type 2 diabetic patients were selected and randomized into two groups, the insulin glargine plus fixed-dose combination glimepiride 1 mg and metformin 500 mg twice daily group (the G/M group) and the insulin glargine plus glimepiride 4 mg once daily group (the G group). The primary endpoint evaluated was change in HbA1c. The secondary endpoints evaluated were changes in fasting blood glucose (FPG), 2-h post prandial glucose (PPG 2 h), insulin, and C-peptide levels. Results: The G/M group was found to have experienced a significantly greater decrease in HbA1c, as well as PPG 2 h compared to the G group. While no significant intergroup difference was found regarding FPG in the ITT, the G/M group in the PP set experienced a significantly greater decrease in FPG. Conclusion: Comparison of combined therapy consisting of either the G/M group or the G group indicated that both forms of therapy are relatively safe but that the former more effectively decreases blood glucose levels. (C) 2019 Elsevier B.V. All rights reserved.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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