Histologic Analysis with the Newly Designed Exoskeleton Seal((R)) Stent-Graft in the Porcine Abdominal Aorta
- Authors
- Park, Jung-Hoon; Cho, Young Kwon; Her, Keun; Jeon, Yong Sun; Kim, Jeong Ho; Seo, Tae-Seok; Song, Myung Gyu
- Issue Date
- Sep-2019
- Publisher
- Springer Verlag
- Keywords
- Exoskeleton stent-graft; Animal studies; Porcine abdominal aorta; Thrombotic occlusions; Neointimal hyperplasia
- Citation
- CardioVascular and Interventional Radiology, v.42, no.9, pp 1331 - 1342
- Pages
- 12
- Journal Title
- CardioVascular and Interventional Radiology
- Volume
- 42
- Number
- 9
- Start Page
- 1331
- End Page
- 1342
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4272
- DOI
- 10.1007/s00270-019-02261-2
- ISSN
- 0174-1551
1432-086X
- Abstract
- PurposeTo investigate the technical feasibility of a novel exoskeleton Seal((R)) stent-graft and analyze early histologic changes in the porcine abdominal aorta.Materials and MethodsSix pigs received an abdominal stent-graft (Group I), and six received an iliac branch stent-graft (Group II). Groups were subdivided as follows: Group Ia, which received three bifurcated main-body stent-grafts; Group Ib, which received three bifurcated main-body stent-grafts with both iliac graft-stents; Group IIa, which received three simple uni-iliac tapered stent-grafts; and Group IIb, which received three uni-iliac tapered tapered stent-grafts with right straight limb and left branched limb. Statistical analyses were performed with the Wilcoxon signed-rank test and mixed-model regression analysis.ResultsThe primary technical success rate (<24h) was 83% because of two acute thromboses in the lumen of the stented abdominal aorta immediately after stent-graft placement. At 4weeks, late thrombosis occurred in two pigs. Higher mean neointimal hyperplasia areas (23.5% vs. 16.2%; P=.047), neointimal hyperplasia thicknesses (545.5 mu m vs. 422.2 mu m; P=.001), and degrees of collagen deposition (2.71 vs. 2.33; P=.002) were observed at the bare-metal stent-graft compared with the proximal exoskeleton portion of the stent-graft, with no significant differences between the patent and occluded groups or among the four types of stent-grafts.ConclusionsThe exoskeleton stent-graft demonstrates 66% of patency rate during 1-month follow-up due to four cases of thromboses; however, the endothelialization on the junction of proximal graft showed no significant differences between the patent and occluded groups. Further studies should investigate long-term outcomes with prolonged neointimal hyperplasia.
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