Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans
- Authors
- Kim, Bo-Kyoung; Kim, Sung-A; Baek, Sun-Mi; Lee, Eun Young; Lee, Eun Soo; Chung, Choon Hee; Ahn, Chan Mug; Park, Sang-Kyu
- Issue Date
- Aug-2019
- Publisher
- International Advancement Center for Medicine & Health Research Co., Ltd. (IACMHR Co., Ltd.)
- Keywords
- Curcumin; Cur2004-8; oxidative stress; aging; Caenorhabditis elegans
- Citation
- Drug discoveries & therapeutics, v.13, no.4, pp 198 - 206
- Pages
- 9
- Journal Title
- Drug discoveries & therapeutics
- Volume
- 13
- Number
- 4
- Start Page
- 198
- End Page
- 206
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4322
- DOI
- 10.5582/ddt.2019.01057
- ISSN
- 1881-7831
1881-784X
- Abstract
- Curcumin, a compound found in Indian yellow curry, is known to possess various biological activities, including anti-oxidant, anti-inflammatory, and anti-cancer activities. Cur2004-8 is a synthetic curcumin derivative having symmetrical bis-alkynyl pyridines that shows a strong anti-angiogenic activity. In the present study, we examined the effect of dietary supplementation with Cur2004-8 on response to environmental stresses and aging using Caenorhabditis elegans as a model system. Dietary intervention with Cur2004-8 significantly increased resistance of C. elegans to oxidative stress. Its anti-oxidative-stress effect was greater than curcumin. However, response of C. elegans to heat stress or ultraviolet irradiation was not significantly affected by Cur2004-8. Next, we examined the effect of Cur2004-8 on aging. Cur2004-8 significantly extended both mean and maximum lifespan, accompanying a shift in time-course distribution of progeny production. Age-related decline in motility was also delayed by supplementation with Cur2004-8. In addition, Cur2004-8 prevented amyloid-beta-induced toxicity in Alzheimer's disease model animals which required a forkhead box (FOXO) transcription factor DAF-16. Dietary supplementation with Cur2004-8 also reversed the increase of mortality observed in worms treated with high-glucose-diet. These results suggest that Cur2004-8 has higher anti-oxidant and anti-aging activities than curcumin. It can be used for the development of novel anti-aging product.
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Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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