Association between Homocysteine Levels and Psoriasis: A Meta-Analysis
- Authors
- Kim, Jung Eun; Lee, Ho Jung; Lee, Jong Suk; Whang, Kyu Uang; Park, Young Lip; Lee, Sung Yul; Kim, Hyun Jung
- Issue Date
- Aug-2019
- Publisher
- 대한피부과학회
- Keywords
- Homocysteine; Meta-analysis; Psoriasis
- Citation
- Annals of Dermatology, v.31, no.4, pp 378 - 386
- Pages
- 9
- Journal Title
- Annals of Dermatology
- Volume
- 31
- Number
- 4
- Start Page
- 378
- End Page
- 386
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4359
- DOI
- 10.5021/ad.2019.31.4.378
- ISSN
- 1013-9087
2005-3894
- Abstract
- Background: Psoriasis is a multifactorial disease associated with an increased risk for metabolic syndrome and cardiovascular diseases. Elevated levels of homocysteine (Hcy) are a marker of cardiovascular risk. Several studies have evaluated the associations between psoriasis and Hcy levels; however, the results remain inconclusive. Objective: We performed a systematic review of the literature and a meta-analysis to better understand the relationship between psoriasis and Hcy. Methods: Five scientific databases (MEDLI NE, Embase, Cochrane Library, Scopus, and Web of Science) were searched to identify relevant studies. A review of 307 publications identified 16 studies that directly assessed plasma levels of Hcy in psoriasis patients. Results: A total of 16 studies including 2,091 subjects were included in the meta-analysis. Hcy levels were significantly higher in psoriasis patients relative to healthy controls (weighted mean difference [WMD], 3.30; 95% confidence interval [CI], 1.58 similar to 5.02; I-2 = 82.1%). Subgroup analyses revealed that patients with higher mean psoriasis area severity index (PASI) scores (PASI> 10) had significantly higher Hcy levels compared to healthy controls (WMD, 4.1 7; 95% CI, 1.18 similar to 7.16; I-2 =88.3%), whereas patients with lower mean PASI scores (PASI <= 10) had not (WMD, 0.76; 95% CI, -1.84 similar to 3.35; I-2 = 72.2%). Conclusion: This meta-analysis found that psoriasis patients, in particular those with PASI > 10, had significantly higher Hcy levels compared to healthy controls. Further research is needed to determine the association between Hcy levels and psoriasis severity.
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Collections - College of Medicine > Department of Dermatology > 1. Journal Articles
- College of Medicine > Department of Dermatology > 1. Journal Articles
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