Clinical characteristics and risk factors for gout flare during the postsurgical periodopen access
- Authors
- Jeong, Hyemin; Jeon, Chan Hong
- Issue Date
- 25-Jul-2019
- Keywords
- Gout; Surgery; Uric acid
- Citation
- Advances in rheumatology, v.59
- Journal Title
- Advances in rheumatology
- Volume
- 59
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4375
- DOI
- 10.1186/s42358-019-0075-7
- ISSN
- 2523-3106
- Abstract
- Objectives: To evaluate the clinical features and risk factors for gout flare during postsurgical period in patients who were previously diagnosed with gout. Methods: Seventy patients who had histories of gout and had been consulted in the rheumatologic clinic before surgery under general anesthesia were included. Clinical characteristics of patients who developed a postsurgical gout flare were compared with those of patients who did not develop gout flare. Results: Among 70 patients, 31 (44.3%) developed gout flare during the postsurgical period. Mean intervals from surgery to gout flare was 3.7days. Flares tended to involve monoarticular joints (61.3%) and affect lower extremity joints (83.9%). Knee joints (26%) and foot joints except the first metatarsophalangeal (MTP) joint (26%) were more frequently involved than the first MTP joint (13%). Presurgical uric acid level >= 9mg/dL (OR 3.77, 95% CI 1.28-11.10, p = 0.016) and amount of uric acid changes between before and after surgery (OR 1.62, 95% CI 1.21-2.18, p = 0.001) were risk factors for postsurgical gout flare. Taking allopurinol reduced the risk of postsurgical gout flare (OR 0.15, 95% CI 0.05-0.45, p = 0.001). Operation time, amount of blood loss during surgery, and surgery site were not significantly associated with postsurgical gout flare. Conclusions: Adequate uric acid control before surgery could prevent the postsurgical gout flare.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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