Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAsopen access
- Authors
- Lee, Min-Woo; Lee, Mihye; Oh, Kyoung-Jin
- Issue Date
- Jun-2019
- Publisher
- MDPI AG
- Keywords
- obesity; type 2 diabetes mellitus; adipokines; batokines; exosomal miRNAs; potential therapeutic targets
- Citation
- Journal of Clinical Medicine, v.8, no.6
- Journal Title
- Journal of Clinical Medicine
- Volume
- 8
- Number
- 6
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4481
- DOI
- 10.3390/jcm8060854
- ISSN
- 2077-0383
- Abstract
- Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For this reason, adipose tissue is considered as the primary site for initiation and aggravation of obesity and T2DM. As a key endocrine organ, the adipose tissue communicates with other organs, such as the brain, liver, muscle, and pancreas, for the maintenance of energy homeostasis. Two different types of adipose tissues-the white adipose tissue (WAT) and brown adipose tissue (BAT)-secrete bioactive peptides and proteins, known as adipokines and batokines, respectively. Some of them have beneficial anti-inflammatory effects, while others have harmful inflammatory effects. Recently, exosomal microRNAs (miRNAs) were identified as novel adipokines, as adipose tissue-derived exosomal miRNAs can affect other organs. In the present review, we discuss the role of adipose-derived secretory factors-adipokines, batokines, and exosomal miRNA-in obesity and T2DM. It will provide new insights into the pathophysiological mechanisms involved in disturbances of adipose-derived factors and will support the development of adipose-derived factors as potential therapeutic targets for obesity and T2DM.
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Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
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