Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetesopen access
- Authors
- Bae, Jung Hwan; Jo, Seung, II; Kim, Seong Jin; Lee, Jong Min; Jeong, Ji Hun; Kang, Jeong Suk; Cho, Nam-Jun; Kim, Sang Soo; Lee, Eun Young; Moon, Jong-Seok
- Issue Date
- Apr-2019
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- ccf-mtDNA; chronic inflammation; AIM2 inflammasome; type 2 diabetes
- Citation
- Cells, v.8, no.4
- Journal Title
- Cells
- Volume
- 8
- Number
- 4
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4593
- DOI
- 10.3390/cells8040328
- ISSN
- 2073-4409
- Abstract
- Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1 (IL-1) levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1 and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4593)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.