Safety and Efficacy of Low-Volume Preparation in the Elderly: Oral Sulfate Solution on the Day before and Split-Dose Regimens (SEE SAFE) Study
- Authors
- Kwak, Min Seob; Cha, Jae Myung; Yang, Hyo-Joon; Park, Dong Il; Kim, Kyeong Ok; Lee, Jun; Shin, Jeong Eun; Joo, Young-Eun; Park, Jongha; Byeon, Jeong-Sik; Kim, Hyun Gun
- Issue Date
- Mar-2019
- Publisher
- 거트앤리버 발행위원회
- Keywords
- Colonoscopy; Cathartics; Safety; Treatment outcome; Aged
- Citation
- Gut and Liver, v.13, no.2, pp 176 - 182
- Pages
- 7
- Journal Title
- Gut and Liver
- Volume
- 13
- Number
- 2
- Start Page
- 176
- End Page
- 182
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4694
- DOI
- 10.5009/gnl18214
- ISSN
- 1976-2283
2005-1212
- Abstract
- Background/Aims: The use of a low-volume bowel cleansing agent is associated with a greater willingness to undergo repeat colonoscopy. Oral sulfate solution (OSS) is a recently approved low-volume agent; however, its efficacy and safety in the elderly population remain unclear. We aimed to evaluate the efficacy, safety, and acceptability of the OSS preparation, in comparison to those of a standard polyethylene glycol (PEG; 4 L) preparation, in elderly patients. Methods: A multicenter, randomized, investigator-blinded study was conducted. Participants were randomized to receive OSS or 4-L PEG with a split-dose regimen. Bowel cleansing efficacy was assessed using the Boston Bowel Preparation Scale (BBPS). Acceptance, satisfaction, and preparation-related symptoms were recorded. Additionally, blood parameters were analyzed for electrolyte abnormalities and nephrotoxicity. Results: A total of 193 patients were analyzed. No group differences in overall bowel cleansing efficacy were observed, with "adequate" preparations achieved in 95.9% (93/97) and 94.8% (91/96) of patients in the OSS and 4L PEG groups, respectively (p=0.747). However, mean BBPS scores for the entire (p=0.010) and right colon (p=0.001) were significantly higher in the OSS group than in the 4-L PEG group. The severity of clinical adverse events and frequency of acute kidney injury were similarly low, and no clinically meaningful electrolyte changes were identified. Self-reported scores regarding amount (p<0.001) and feeling (p=0.007), as well as overall satisfaction (p=0.001) and willingness to repeat the preparation (92.8% vs 67.7%, p<0.001), were significantly better in the OSS group than in the 4-L PEG group. Conclusions: In elderly individuals, OSS with a split-dose regimen has greater acceptability and comparable efficacy in bowel cleansing compared to 4-L PEG.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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