Anti-Inflammatory Activity of Populus deltoides Leaf Extract via Modulating NF-kappa B and p38/JNK Pathwaysopen access
- Authors
- Jeong, Ye Eun; Lee, Mi-Young
- Issue Date
- Dec-2018
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- anti-inflammation; Populus deltoides leaf; iNOS; MAPK; NF-kappa B
- Citation
- International Journal of Molecular Sciences, v.19, no.12
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 19
- Number
- 12
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5443
- DOI
- 10.3390/ijms19123746
- ISSN
- 1661-6596
1422-0067
- Abstract
- Populus deltoides, known as eastern cottonwood, has been commonly used as a medicinal plant. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory activity of P. deltoides leaf extract (PLE). PLE effectively inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, but not that of cyclooxygenase-2 (COX-2) and prostaglandin E2. Proinflammatory tumor necrosis factor alpha (TNF-alpha) levels were also reduced by the extract. PLE inhibited the phosphorylation of nuclear factor-kappa B (NF-kappa B) and inhibitor of Kappa B alpha (I kappa B alpha), and blunted LPS-triggered enhanced nuclear translocation of NF-kappa B p65. In mitogen-activated protein kinase (MAPK) signaling, PLE effectively decreased the phosphorylation of p38 and c-Jun N-terminal protein kinase (JNK), but not of extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these results suggest that anti-inflammatory activity of P. deltoides leaf extract might be driven by iNOS and NO inhibition mediated by modulation of the NF-kappa B and p38/JNK signaling pathways.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5443)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.