Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activityopen access
- Authors
- Jin, Solee; Lee, Mi-Young
- Issue Date
- Nov-2018
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- Kaempferia parviflora; anti-inflammation; sebostatic effect; anti-P. acnes effect
- Citation
- International Journal of Molecular Sciences, v.19, no.11
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 19
- Number
- 11
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5543
- DOI
- 10.3390/ijms19113457
- ISSN
- 1661-6596
1422-0067
- Abstract
- Kaempferia parviflora, referred to as black ginger, has traditionally been used as a health-promoting alternative medicine. In this study, we examined the anti-inflammatory, sebostatic, and anti-Propionibacterium acnes activities of K. parviflora extract. The extract significantly down-regulated the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) level. Moreover, the phosphorylation of IkB alpha and nuclear factor-kappa B (NF-kappa B), and the enhanced nuclear translocation of NF-kappa B p65 in lipopolysaccharide-stimulated murine macrophage-like cell line (RAW 264.7) cells were markedly decreased by the extract. Notably, the main component of K. parviflora, 5,7-dimethoxyflavone, also modulated the expression of iNOS and NF-kappa B signal molecules in P. acnes-stimulated human keratinocyte (HaCaT) cells. Additionally, K. parviflora extract inhibited the lipogenesis of sebocytes, as evidenced by a reduced level of triglyceride and lipid accumulation in the sebocytes. The sebostatic effect was also confirmed by a reduced expression of peroxisome proliferation-activating receptors (PPAR-gamma) and oil-red O staining in sebocytes. Taken together, this study suggests for the first time that K. parviflora extract could be developed as a potential natural anti-acne agent with anti-inflammatory, sebostatic, and anti-P. acnes activity.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5543)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.