Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Determination of Zinc Pyrithione and Pyrithione in Shampoos
- Authors
- Kim, T. H.; Jung, G. H.; Lee, E. H.; Park, H. R.; Lee, J. K.; Kim, H. G.
- Issue Date
- Sep-2018
- Publisher
- Uniwersytet Slaski w Katowicach
- Keywords
- Pyrithione; zinc pyrithione; LC-MS/MS; liquid-liquid extraction; shampoos
- Citation
- Acta Chromatographica, v.30, no.3, pp 200 - 205
- Pages
- 6
- Journal Title
- Acta Chromatographica
- Volume
- 30
- Number
- 3
- Start Page
- 200
- End Page
- 205
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5700
- DOI
- 10.1556/1326.2017.00294
- ISSN
- 1233-2356
2083-5736
- Abstract
- A simple, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of zinc pyrithione (ZnPT) and pyrithione (PT) in shampoos. The method consisted of a liquid-liquid extraction for sample preparation. The mass spectrometer was operated in multiple reaction monitoring (MRM) mode via the positive electrospray ionization interface. A linear regression (weighted 1/x) was used to fit calibration curves over the concentration range of 50-2000 ng/mL for both ZnPT and PT Excellent linearity (r(2) >= 0.9996) was achieved for all. The method was validated and found to be accurate (95.9-108.2% for ZnPT and 94.9-110.4% for PT), precise, and selective. Analytes in shampoos were found to be stable in the autosampler (6 degrees C for 6 h), in room temperature (for 6 h), and after three freeze-thaw cycles, and recovery of analytes was reproducible (90.8-94.6% for ZnPT and 90.2-96.3% for PT).
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