Microscopic hematuria is a risk factor of incident chronic kidney disease in the Korean general population: a community-based prospective cohort study
- Authors
- Kim, H.; Lee, M.; Cha, M. -U.; Nam, K. H.; An, S. Y.; Park, S.; Jhee, J. H.; Yun, H. -R.; Kee, Y. K.; Park, J. T.; Yoo, T. -H.; Kang, S. -W.; Han, S. H.
- Issue Date
- Jun-2018
- Publisher
- Oxford University Press
- Keywords
- Microscopic hematuria
- Citation
- QJM - Monthly Journal of the Association of Physicians, v.111, no.6, pp 389 - 397
- Pages
- 9
- Journal Title
- QJM - Monthly Journal of the Association of Physicians
- Volume
- 111
- Number
- 6
- Start Page
- 389
- End Page
- 397
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5928
- DOI
- 10.1093/qjmed/hcy054
- ISSN
- 1460-2725
1460-2393
- Abstract
- Background: Although asymptomatic microscopic hematuria (MH) is a common finding in clinical practice, its long-term outcome remains unknown. Aim: This study evaluated the clinical implication of MH in the general population using a large-scale long-term longitudinal cohort database. Methods: This study included 8719 participants from the Korean Genome and Epidemiology Study between 2001 and 2014. MH was defined as >= 5 red blood cells per high-power field in random urinalysis without evidence of pyuria. The primary study outcome measure was incident chronic kidney disease (CKD), defined as estimated glomerular filtration rate <60 ml min(-1) .1.73.m(-2). Results: During a median follow-up of 11.7 years, CKD occurred in 677 (7.8%) subjects. In Cox regression after adjustment for multiple confounders, subjects with MH had a significantly higher risk of incident CKD than those without [hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.12-1.87; P = 0.005]. Isolated MH without proteinuria was also a risk factor of incident CKD (HR 1.37, 95% CI 1.04-1.79; P = 0.023) and the risk was further increased in MH with concomitant proteinuria (HR 5.41, 95% CI 2.54-11.49; P<0.001). In propensity score matching analysis after excluding subjects with proteinuria, multi-variable stratified Cox regression analysis revealed that subjects with isolated MH had a significantly higher risk of incident CKD than those without (HR 1.83, 95% CI 1.14-2.94; P = 0.012). Conclusion: The presence of MH is associated with an increased risk of incident CKD in the general population. Therefore, attentive follow-up is warranted in persons with MH for early detection of CKD.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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