The Effect of Biocomposite Screws on Bone Regeneration in a Rat Osteoporosis Model
- Authors
- Jeong, Je Hoon; Jin, Eun-Sun; Kim, Ji Yeon; Lee, Bora; Min, JoongKee; Jeon, Sang Ryong; Lee, Minsu; Choi, Kyoung Hyo
- Issue Date
- Oct-2017
- Publisher
- Elsevier BV
- Keywords
- Animal model; Biodegradable screw; Bone morphogenetic protein 2; Osteoporosis; Screw
- Citation
- World Neurosurgery, v.106, pp 964 - 972
- Pages
- 9
- Journal Title
- World Neurosurgery
- Volume
- 106
- Start Page
- 964
- End Page
- 972
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7146
- DOI
- 10.1016/J.WNEU.2017.07.083
- ISSN
- 1878-8750
1878-8769
- Abstract
- OBJECTIVE: To evaluate the efficacy of biocomposite screws used in ovariectomy (OVX)-induced osteoporotic rats. METHODS: Twenty-four female Wistar rats (250-300 g, 12 weeks old) were divided into 4 groups: sham group (control), OVX-induced osteoporosis group (OVX), OVX and biodegradable poly(lactic-co-glycolic acid) (PLGA) without tricalcium phosphate (beta-TCP) screw insertion group (OVX/BSR), and OVX and biocomposite (PLGA with b-TCP) screw insertion group (OVX/CSR). Three groups underwent bilateral OVX, and of these, 2 groups had 2 different types of screw inserted at the proximal tibia. At 25 weeks after OVX, the bilateral tibias were extracted. The extracted tibiae were scanned by ex vivo micro-computed tomography (CT) and stained with hematoxylin and eosin (H&E) and with Masson's trichrome stain for pathological assessment. RESULTS: Compared with the ovariectomized groups, the control group had the highest values for bone mineral density (BMD), bone volume (BV)/total volume (TV), and trabecular number (Tb.N) and the lowest values for trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp). In the pairwise comparison among ovariectomized groups, the OVX/CSR group had significantly higher BMD, BV/TV, and Tb.N values than the other 2 groups (OVX and OVX/BSR) and significantly lower Tb.Sp. Micro-CT scans showed clear evidence of new trabecular formation near the screw insertion site in the OVX/CSR group only. Analyses of H&E- and Masson's trichrome-stained sections showed more and thicker trabecular bone around the implant in the OVX/CSR group compared with the OVX and OVX/BSR groups. CONCLUSIONS: Biocomposite screws can improve local bone quality and facilitate osteoconductivity in an osteoporotic rat model.
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Collections - College of Medicine > Department of Neurosurgery > 1. Journal Articles
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