Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis modelopen access
- Authors
- Jeong, Hyemin; Bae, Eun-Kyung; Kim, Hunnyun; Eun, Yeong Hee; Kim, In Young; Kim, Hyungjin; Lee, Jaejoon; Jeon, Chan Hong; Koh, Eun-Mi; Cha, Hoon-Suk
- Issue Date
- 7-Sep-2017
- Publisher
- BioMed Central
- Keywords
- Estrogen; Spondyloarthritis; Mice
- Citation
- Arthritis Research & Therapy, v.19
- Journal Title
- Arthritis Research & Therapy
- Volume
- 19
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7217
- DOI
- 10.1186/s13075-017-1407-9
- ISSN
- 1478-6354
1478-6362
- Abstract
- Background: Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA). Methods: The effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17 beta-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and F-18-fluorodeoxyglucose (F-18-FDG) small-animal positron emission tomography/computed tomography performed to quantify joint inflammation. The expression of inflammatory cytokines in joint tissue was measured. Results: E2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc. F-18-FDG uptake was significantly lower in E2-treated mice than in sham-operated (sham) and ovariectomized mice. Expression of TNF, interferon-gamma, and IL-17A was significantly reduced in E2-treated mice, whereas expression of sclerostin and Dickkopf-1 was increased in E2-treated mice compared with sham and ovariectomized mice. Conclusions: Estrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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