The serum pepsinogen levels for risk assessment of gastric neoplasms New proposal from a case-control study in Koreaopen access
- Authors
- Cho, Jun-Hyung; Jeon, Seong Ran; Kim, Hyun Gun; Jin, So-Young; Park, Suyeon
- Issue Date
- Jul-2017
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- atrophy; gastric neoplasm; Helicobacter pylori; pepsinogen; risk
- Citation
- Medicine, v.96, no.29
- Journal Title
- Medicine
- Volume
- 96
- Number
- 29
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7397
- DOI
- 10.1097/MD.0000000000007603
- ISSN
- 0025-7974
1536-5964
- Abstract
- To decrease the gastric cancer related mortality rate, endoscopic screening is widely performed in Korea. However, a precise method for identifying those at a high risk of gastric neoplasms has not been established. This study aims to evaluate serum pepsinogen (PG) levels for risk assessment of gastric neoplasms. Between August 2014 and March 2016, a total of 398 subjects, including 87 with gastric neoplasms, were enrolled in this study. On the basis of the serum PG I/II ratio, the enrolled subjects were classified into 4 groups: group A, PG I/II ratio > 4; group B, > 3 and <= 4; group C, > 2 and <= 3; group D, <= 2. Compared with group A, a stepwise increase in the risk of gastric neoplasm was observed from group B [ odds ratio (OR) = 9.9, 95% confidence interval (95% CI) = 4.0-24.4] to group C (OR = 20.9, 95% CI = 8.7-50.5) to group D (OR = 37.3, 95% CI = 14.3-97.4). The optimal cutoff value of the serum PG I/II ratio for predicting gastric neoplasms was 4.5, with a sensitivity of 97.7% and a specificity of 57.6%. A decrease in the serum PG I/II ratio was strongly associated with an increased risk of gastric neoplasms. The serum PG I/II ratio can be used to identify those at a high risk of gastric neoplasms in Korean population.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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