Prognostic value of bone marrow F-18-FDG uptake on PET/CT in lymphoma patients with negative bone marrow involvement
- Authors
- Lee, Jeong Won; Lee, Sang-Cheol; Kim, Han Jo; Lee, Sang Mi
- Issue Date
- Jan-2017
- Publisher
- Hellenic Society of Nuclear Medicine
- Keywords
- Lymphoma; F-18-FDG PET; Bone marrow; Prognosis
- Citation
- Hellenic Journal of Nuclear Medicine, v.20, no.1, pp 17 - 25
- Pages
- 9
- Journal Title
- Hellenic Journal of Nuclear Medicine
- Volume
- 20
- Number
- 1
- Start Page
- 17
- End Page
- 25
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7907
- ISSN
- 1790-5427
- Abstract
- OBJECTIVE:The study evaluated the significance of F-18 fluorodeoxyglucose (F-18-FDG) uptake of bone marrow (BM) for predicting progression-free survival (PFS) in lymphoma patients without BM involvement. SUBJECTS AND METHODS:Ninety-five patients with histopathologically proven lymphoma, 7 Hodgkin's lymphoma and 88 non-Hodgkin's lymphoma, who underwent F-18-FDG positron emission tomography/computed tomography (PET/CT) and BM biopsy for staging work-up and 40 normal subjects were retrospectively enrolled. Maximal F-18-FDG uptake of lymphoma (Lmax), mean F-18-FDG uptake of BM (BM SUV) and BM-to-liver uptake ratio (BLR) were measured. Prognostic value of BM SUV and BLR for predicting PFS were assessed. RESULTS:Of the 95 patients, 35 (36.8%) were histopathologically or clinically diagnosed with BM involvement of lymphoma. There were significant differences of BLR among lymphoma patients with/without BM involvement and normal subjects (P<0.05). For all patients, high risk indicated by International Prognostic Index (IPI) score and Lmax were significantly associated with PFS on multivariate analysis (P<0.05). For 60 patients without BM involvement, BM SUV and BLR were independent prognostic factors for PFS along with performance status and Lmax (p<0.05). Among patients without BM involvement, high F-18-FDG uptake of BM was associated with significantly worse PFS than low F-18-FDG uptake of BM, with no significant difference in PFS apparent compared to patients with BM involvement. CONCLUSION:In lymphoma patients without BM involvement, F-18-FDG uptake of BM was significantly associated with worse PFS. Patients with high F-18-FDG uptake of BM showed similar prognosis to those with BM involvement.
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Collections - College of Medicine > Department of Radiology > 1. Journal Articles
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