Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signaling pathway in diet-induced obesity mouse modelopen access
- Authors
- Baek, Hye Kyung; Kim, Pan Soo; Song, Ji Ae; Choi, Dong-Hwa; Kim, Do Eun; Il Oh, Seung; Park, Sang-Kyu; Kim, Sung-Jo; Song, Ki-Duk; Hwang, In Koo; Seo, Hyung Seok; Yi, Sun Shin
- Issue Date
- 2017
- Publisher
- 대한수의학회
- Keywords
- Artemisia annua; anti-obesity; cyclooxygenase 2; neurogenesis; neuro-maturation
- Citation
- Journal of Veterinary Science, v.18, no.2, pp 119 - 127
- Pages
- 9
- Journal Title
- Journal of Veterinary Science
- Volume
- 18
- Number
- 2
- Start Page
- 119
- End Page
- 127
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8384
- DOI
- 10.4142/jvs.2017.18.2.119
- ISSN
- 1229-845X
1976-555X
- Abstract
- Recently, we reported that Artemisia annua (AA) has anti-adipogenic properties in vitro and in vivo. Reduction of adipogenesis by AA treatment may dampen systemic inflammation and protect neurons from cytokine-induced damage. Therefore, the present study was undertaken to assess whether AA increases neuronal maturation by reducing inflammatory responses, such as those mediated by cyclooxygenase 2 (COX-2). Mice were fed normal chow or a high-fat diet with or without chronic daily oral administration of AA extract (0.2 g/10 mL/kg) for 4 weeks; then, changes in their hippocampal dentate gyri were measured via immunohistochemistry/immunofluorescence staining for bromodexoxyuridine, doublecortin, and neuronal nuclei, markers of neuronal maturation, and quantitative western blotting for COX-2 and Iba-1, in order to assess correlations between systemic inflammation (interleukin-6) and food type. Additionally, we tested the effect of AA in an Alzheimer's disease model of Caenorhabditis elegans and uncovered a potential benefit. The results show that chronic AA dosing significantly increases neuronal maturation, particularly in the high-fat diet group. This effect was seen in the absence of any changes in COX-2 levels in mice given the same type of food, pointing to the possibility of alternate anti-inflammatory pathways in the stimulation of neurogenesis and neuro-maturation in a background of obesity.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
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