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A new duet in cancer biology: AMPK the typical and UBE2O the atypical
- Authors
- Vila, Isabelle K.; Song, Su Jung; Song, Min Sup
- Issue Date
- 2017
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- AMPK; AMPK alpha 2; arsenite; breast cancer; cancer metabolism; HIF1 alpha; mTOR; prostate cancer; UBE2O; ubiquitination
- Citation
- MOLECULAR & CELLULAR ONCOLOGY, v.4, no.3
- Journal Title
- MOLECULAR & CELLULAR ONCOLOGY
- Volume
- 4
- Number
- 3
- ISSN
- 2372-3556
- Abstract
- Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1-hypoxia-inducible factor 1-alpha pathway. Critically, UBE2O targets adenosine monophosphate (AMP)-activated protein kinase-alpha 2 (AMPK alpha 2) for ubiquitination and degradation. We thus suggest the UBE2O-AMPK alpha 2 axis as a potential therapeutic target for cancer.
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Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
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Related Researcher
- SONG, SU JUNG
- College of Medicine (Department of Biochemistry)