Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats
- Authors
- Lee, Min Jung; Jang, Minhee; Bae, Chun-Sik; Park, Kyoung-Sun; Kim, Hak-Jae; Lee, Sanghyun; Lee, Sang Won; Kim, Young Ock; Cho, Ik-Hyun
- Issue Date
- Dec-2016
- Publisher
- Mary Ann Liebert Inc.
- Keywords
- Kyung-Ok-Ko; dehydroepiandrosterone; endometrial abnormality; polycystic ovary syndrome
- Citation
- Rejuvenation Research, v.19, no.6, pp 456 - 466
- Pages
- 11
- Journal Title
- Rejuvenation Research
- Volume
- 19
- Number
- 6
- Start Page
- 456
- End Page
- 466
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8578
- DOI
- 10.1089/rej.2015.1787
- ISSN
- 1549-1684
1557-8577
- Abstract
- A traditional herbal prescription Kyung-Ok-Ko (KOK), composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquilaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in Oriental medicine as an invigorant for age-related diseases, such as amnesia and stroke. However, the beneficial value of KOK on uterine dysfunction related to hyperandrogenism is largely unknown. We investigated the effect of KOK (2.0 g/kg/day, per os) on endometrial abnormalities in a dehydroepiandrosterone (DHEA, subcutaneous)-induced polycystic ovary syndrome (PCOS) rat model. Preadministration of KOK significantly (p < 0.05) decreased the elevated body weight, uterus weight, and endometrial thickness by PCOS induction, corresponding to reduced apoptosis and the infiltration of immune cells (CD4(+) T cells, CD8(+) T cells, and macrophages) in the endometrium. These results were associated with reduced mRNA expression of interleukin (IL)-1 beta, IL-6, IL-8, and matrix metalloproteinase-3 and increased mRNA expression of IGF-beta 1, transforming growth factor (TGF)-beta, TGF-beta 1, and vascular endothelial growth factor in the uterus after DHEA injection. These multiple effects of KOK may synergistically prevent the development of endometrial abnormalities in DHEA-induced hyperandrogenism via anti-inflammatory action, indicating that KOK has preventive and therapeutic potential for suppressing PCOS.
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