Fluoroquinolone resistance of Streptococcus pneumoniae isolates causing invasive disease: special focus on zabofloxacin

Abstract

The present study examined the in vitro activity of various antibiotics including zabofloxacin, against isolates responsible for invasive pneumococcal diseases. Between 1997 and 2008, a total of 208 isolates were collected from sterile fluids, including blood (n = 196, 94.2%), pleural fluid (n = 5, 2.4%), cerebrospinal fluid (n = 5, 2.4%), and ascites (n = 2, 1.0%). Zabofloxacin showed the lowest MIC50 (0.015 mu g/mL) and MIC50 (0.025 mu g/mL) values of all the tested antibiotics. Rates of isolates resistant to penicillin (MIC >= ng/mL), ceftriaxone (MIC >= 4 mu g/mL) and levofloxacin (MIC >= 8 mu g/mL) were 3.4%, 0.4% and 2.0%, respectively. Four isolates (2.0%) were resistant to levofloxacin, and zabofloxacin showed low MICs (range, 0.025-0.125 mu g/mL). Zabofloxacin shows potent in vitro activity against S. pneumoniae isolates that caused invasive disease, even strains that are resistant to levofloxacin. (C) 2016 Published by Elsevier Inc.