Cerebrospinal Fluid Pressure and Trans-lamina Cribrosa Pressure Difference in Open-angle Glaucoma: KNHANES V
- Authors
- Kim, Yoon Kyung; Tumurbaatar, Undarmaa; Ohn, Young-Hoon; Ha, Seung Joo; Park, Ka Hee
- Issue Date
- Sep-2016
- Publisher
- 대한안과학회
- Keywords
- Cerebrospinal fluid pressure; Open-angle glaucoma; Trans-lamina cribrosa pressure difference
- Citation
- 대한안과학회지, v.57, no.9, pp 1392 - 1399
- Pages
- 8
- Journal Title
- 대한안과학회지
- Volume
- 57
- Number
- 9
- Start Page
- 1392
- End Page
- 1399
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8826
- DOI
- 10.3341/jkos.2016.57.9.1392
- ISSN
- 0378-6471
2092-9374
- Abstract
- Purpose: To investigate the relationships between estimated cerebrospinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) in open-angle glaucoma (OAG) in Korean population. Methods: A total of 10,801 eyes were included from the Korean National Health and Nutrition Examination Survey V. All participants (aged 19 years or older) were classified as non-glaucomatous group, OAG suspect group and OAG group. CSFP was calculated as CSFP (mm Hg) = 0.44 body mass index (kg/m(2)) + 0.16 diastolic blood pressure (mm Hg) - 0.18 age (years) - 1.91. TLCPD was calculated by subtracting CSFP from intraocular pressure. Results: The mean estimated CSFP was (8.7 +/- 3.3 mm Hg vs. 11.6 +/- 3.7 mm Hg, 11.2 +/- 3.8 mm Hg vs. 11.6 +/- 3.7 mm Hg) was lower, and the mean TLCPD (5.7 +/- 4.4 mm Hg vs. 2.2 +/- 4.4 mm Hg, 3 +/- 4.7 mm Hg vs. 2.2 +/- 4.4 mm Hg) was higher in the OAG group and in the OAG suspect group than in the non-glaucomatous control group, respectively (p < 0.001). After adjusting relating factor with CSFP and TLCPD using simple linear regression and multivariate analyses, the mean estimated CSFP was distributed lower (p < 0.001; beta: -0.12; B: -2.306; 95% confidence interval [CI]: -2.717, -1.895) in OAG group than in non-glaucomatous group and the mean TLCPD was distributed higher (p < 0.001; beta: 0.099; B: 1.349; 95% CI: 0.977, 1.72; p < 0.001; beta: 0.118; B: 2.776; 95% CI: 2.264, 3.289) in OAG suspect group and in OAG group than in non-glaucomatous group, respectively. Conclusions: Estimated CSFP and calculated TLCPD showed essential association with OAG presence. It supports the potential role of low CSFP in the pathogenesis of OAG.
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Collections - College of Medicine > Department of Ophthalmology > 1. Journal Articles
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