Detailed Information
Cited 0 time in 
Cited 58 time in 
Cited 58 time in
Metadata Downloads
Distinct intrathecal interleukin-17/interleukin-6 activation in anti-N-methyl-D-aspartate receptor encephalitis
- Authors
- Byun, Jung-Ick; Lee, Soon-Tae; Moon, Jangsup; Jung, Keun-Hwa; Sunwoo, Jun-Sang; Lim, Jung-Ah; Kim, Tae-Joon; Shin, Yong-Won; Lee, Keon-Joo; Jun, Jin-Sun; Lee, Han Sang; Lee, Woo-Jin; Kim, Young-Sook; Kim, Soyun; Jeon, Daejong; Park, Kyung-Il; Jung, Ki-Young; Kim, Manho; Chu, Kon; Lee, Sang Kun
- Issue Date
- 15-Aug-2016
- Publisher
- Elsevier BV
- Keywords
- Cytokine; Autoimmune encephalitis; NMDAR; LGI1; IL-17A; IL-6; CXCL13
- Citation
- Journal of Neuroimmunology, v.297, pp 141 - 147
- Pages
- 7
- Journal Title
- Journal of Neuroimmunology
- Volume
- 297
- Start Page
- 141
- End Page
- 147
- ISSN
- 0165-5728
1872-8421
- Abstract
- The aim of this study was to compare serum and cerebrospinal fluid (CSF) cytokine/chemokine levels between anti-NMDAR and anti-LGI1 encephalitis patients. Samples from fourteen anti-NMDAR encephalitis patients, ten anti-LGI1 encephalitis patients, and ten controls were analyzed for the following cytokines/chemokines: IL-1b, IL-2, IL-4, IL-5, IL-6,IL-10, IL-12, IL-13, IL-17A, IL-23, GM-CSF, IFN-gamma, TNF-alpha, and CXCL13. Compared with controls, CSF IL-17A, IL-6 and CXCL13 were elevated in anti-NMDAR encephalitis patients (post-hoc p-values 0.002, 0.011, and 0.011, respectively) but not in anti-LGI1 encephalitis patients. In the serum, only IL-2 was increased in anti-NMDAR encephalitis. Intrathecal IL-17/IL-6 activation is a characteristic of anti-NMDAR encephalitis. (C) 2016 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Neurology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.