Involvement of T cells in early evolving segmental vitiligo
- Authors
- Shin, J.; Kang, H. Y.; Kim, K. H.; Park, C. J.; Oh, S. H.; Lee, S. C.; Lee, S.; Choi, G. S.; Hann, S. K.
- Issue Date
- Aug-2016
- Publisher
- Blackwell Publishing Inc.
- Keywords
- Involvement of T cells; evolving segmental vitiligo
- Citation
- Clinical and Experimental Dermatology, v.41, no.6, pp 671 - 674
- Pages
- 4
- Journal Title
- Clinical and Experimental Dermatology
- Volume
- 41
- Number
- 6
- Start Page
- 671
- End Page
- 674
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8923
- DOI
- 10.1111/ced.12852
- ISSN
- 0307-6938
1365-2230
- Abstract
- Recent studies have suggested an overlapping autoimmune mechanism between segmental vitiligo (SV) and nonsegmental vitiligo (NSV). Although T-cell infiltration is observed in the margins of active lesions in NSV, the histopathological characteristics of the active margin of SV are not well known. To determine if T-cell inflammatory responses are present in the active margin of SV lesions, biopsies were taken from the active margin of a lesion in 12 patients with early or actively spreading SV and compared with a normal control sample (on the symmetrical, opposite site of the same dermatome). The samples were stained for CD4, CD8, CD25 and interferon-. Lymphocytic infiltration was seen in 70% of patients. CD4+ T cells infiltrated the dermis, while CD8+ T cells were present in the epidermis or attached to the basal layer. The increase in the number of CD8+ T cells was significant (P < 0.04), while CD4+ or CD25+ T cells also appeared to be increased in number, but this was not significant. These results suggest that SV also has an autoimmune mechanism in the early evolving stage.
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Collections - College of Medicine > Department of Dermatology > 1. Journal Articles
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