Hypoxia-Responsive Mesoporous Nanoparticles for Doxorubicin Deliveryopen access
- Authors
- Khatoon, S.[Khatoon, S.]; Han, H.S.[Han, H.S.]; Jeon, J.[Jeon, J.]; Rao, N.V.[Rao, N.V.]; Jeong, D.-W.[Jeong, D.-W.]; Ikram, M.[Ikram, M.]; Yasin, T.[Yasin, T.]; Yi, G.-R.[Yi, G.-R.]; Park, J.H.[Park, J.H.]
- Issue Date
- Apr-2018
- Publisher
- MDPI
- Keywords
- Doxorubicin; Hypoxia; Mesoporous silica nanoparticles; Nitroimidazole; β-cyclodextrin
- Citation
- POLYMERS, v.10, no.4
- Indexed
- SCIE
SCOPUS
- Journal Title
- POLYMERS
- Volume
- 10
- Number
- 4
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/20482
- DOI
- 10.3390/polym10040390
- ISSN
- 2073-4360
- Abstract
- Hypoxia, or low oxygen tension, is a common feature of solid tumors. Here, we report hypoxia-responsive mesoporous silica nanoparticles (HR-MSNs) with a 4-nitroimidazole-beta-cyclodextrin (NI-CD) complex that is acting as the hypoxia-responsive gatekeeper. When these CD-HR-MSNs encountered a hypoxic environment, the nitroimidazole (NI) gatekeeper portion of CD-HR-MSNs disintegrated through bioreduction of the hydrophobic NI state to the hydrophilic NI state. Under hypoxic conditions, the release rate of doxorubicin (DOX) from DOX-loaded CD-HR-MSNs (DOX-CD-HR-MSNs) increased along with the disintegration of the gatekeeper. Conversely, DOX release was retarded under normoxic conditions. In vitro experiments confirmed that DOX-CD-HR-MSNs exhibit higher toxicity to hypoxic cells when compared to normoxic cells. Confocal microscopy images indicated that DOX-CD-HR-MSNs effectively release DOX into SCC-7 cells under hypoxic conditions. These results demonstrate that CD-HR-MSNs can release drugs in a hypoxia-responsive manner, and thus are promising drug carriers for hypoxia-targeted cancer therapy.
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Collections - Engineering > Chemical Engineering > 1. Journal Articles
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