ROS-responsive mesoporous silica nanoparticles for MR imaging-guided photodynamically maneuvered chemotherapy
- Authors
- Vijayakameswara Rao, N.[Vijayakameswara Rao, N.]; Han, H.S.[Han, H.S.]; Lee, H.[Lee, H.]; Nguyen, V.Q.[Nguyen, V.Q.]; Jeon, S.[Jeon, S.]; Jung, D.-W.[Jung, D.-W.]; Lee, J.[Lee, J.]; Yi, G.-R.[Yi, G.-R.]; Park, J.H.[Park, J.H.]
- Issue Date
- 28-May-2018
- Publisher
- Royal Society of Chemistry
- Citation
- Nanoscale, v.10, no.20, pp.9616 - 9627
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nanoscale
- Volume
- 10
- Number
- 20
- Start Page
- 9616
- End Page
- 9627
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/24352
- DOI
- 10.1039/c8nr00888d
- ISSN
- 2040-3364
- Abstract
- Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gatekeepers have been extensively investigated for controlled drug delivery at the target sites. Herein, we developed reactive oxygen species (ROS)-responsive MSNs (R-MSNs), consisting of a gadolinium (Gd)-DOTA complex as the ROS-responsive gatekeeper and polyethylene glycol (PEG)-conjugated chlorin e6 as the ROS generator, for magnetic resonance (MR) imaging-guided photodynamic chemotherapy. Doxorubicin (DOX), chosen as an anticancer drug, was physically encapsulated into DOTA-conjugated MSNs, followed by chemical crosslinking via the addition of GdCl3. DOX-R-MSNs could effectively maintain their structural integrity in a physiological environment for 7 days and show an enhanced in vitro T1-MR imaging signal for the Gd-DOTA complex. Upon 660 nm laser irradiation, the release rate of DOX from DOX-R-MSNs remarkably increased along with the disintegration of the gatekeeper, whereas DOX release was significantly retarded without irradiation. When DOX-R-MSNs were intravenously injected into tumor-bearing mice, they were effectively accumulated in tumor tissue, which was demonstrated using MR imaging. In addition, tumor growth was significantly suppressed by DOX-R-MSNs, allowing for site-specific release of DOX in a photodynamically maneuvered manner. Overall, these results suggest that R-MSNs have potential as drug carriers for MR imaging-guided photodynamic chemotherapy. © 2018 The Royal Society of Chemistry.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Engineering > Chemical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.