Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features
- Authors
- Ahn S.[Ahn S.]; Kwon G.Y.[Kwon G.Y.]; Cho Y.M.[Cho Y.M.]; Jun S.-Y.[Jun S.-Y.]; Choi C.[Choi C.]; Kim H.-J.[Kim H.-J.]; Park Y.W.[Park Y.W.]; Park W.S.[Park W.S.]; Shim J.W.[Shim J.W.]
- Issue Date
- Dec-2013
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Acquired cystic disease; c-met; Renal cell carcinoma; Target therapy
- Citation
- MEDICAL MOLECULAR MORPHOLOGY, v.46, no.4, pp.225 - 232
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDICAL MOLECULAR MORPHOLOGY
- Volume
- 46
- Number
- 4
- Start Page
- 225
- End Page
- 232
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/58341
- DOI
- 10.1007/s00795-013-0028-x
- ISSN
- 1860-1480
- Abstract
- Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a subtype of renal cell carcinoma (RCC) with unique morphologic features found exclusively in the background of end-stage renal disease. We analyzed the clinicopathologic features and immumoreactive profiles of 12 cases of ACD-RCC to further characterize this recently recognized entity. Review of histologic slides was performed in conjunction with immunohistochemical staining directed to the contemporary diagnostic antibodies and the putative target therapy-related markers. Histologically, the tumors showed characteristic inter-or intracellular microlumens and eosinophilic tumor cells. Intratumoral hemosiderin deposition and degenerating foamy tumor cells were consistent findings which were not previously described. Immunohistochemically, all the tumors were positive for alpha-methylacyl-CoA-racemase, CD10, pan-cytokeratin, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and c-met, while negative for carbonic anhydrase-9, CD57, CD68, c-kit, pax-2, platelet-derived growth factor receptor (PDGFR)-alpha or vascular endothelial growth factor receptor (VEGFR)-2. Heterogenous staining was found for CK7 and kidney-specific cadherin. Positive reaction to c-met suggests its utility as a plausible therapeutic target in ACD-RCC. Thus, we present the unique morphologic and immunopathologic features of ACD-RCC, which may be helpful in both diagnostic and therapeutic aspects.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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