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Butler enables rapid cloud-based analysis of thousands of human genomesopen access
- Authors
- Yakneen, S[Yakneen, Sergei]; Waszak, SM[Waszak, Sebastian M.]; Gertz, M[Gertz, Michael]; Korbel, JO[Korbel, Jan O.]; Aminou, B[Aminou, Brice]; Bartolome, J[Bartolome, Javier]; Boroevich, KA[Boroevich, Keith A.]; Boyce, R[Boyce, Rich]; Brooks, AN[Brooks, Angela N.]; Buchanan, A[Buchanan, Alex]; Buchhalter, I[Buchhalter, Ivo]; Butler, AP[Butler, Adam P.]; Byrne, NJ[Byrne, Niall J.]; Cafferkey, A[Cafferkey, Andy]; Campbell, PJ[Campbell, Peter J.]; Chen, ZH[Chen, Zhaohong]; Cho, S[Cho, Sunghoon]; Choi, W[Choi, Wan]; Clapham, P[Clapham, Peter]; Davis-Dusenbery, BN[Davis-Dusenbery, Brandi N.]; De La Vega, FM[De La Vega, Francisco M.]; Demeulemeester, J[Demeulemeester, Jonas]; Dow, MT[Dow, Michelle T.]; Dursi, LJ[Dursi, Lewis Jonathan]; Eils, J[Eils, Juergen]; Eils, R[Eils, Roland]; Ellrott, K[Ellrott, Kyle]; Farcas, C[Farcas, Claudiu]; Favero, F[Favero, Francesco]; Fayzullaev, N[Fayzullaev, Nodirjon]; Ferretti, V[Ferretti, Vincent]; Flicek, P[Flicek, Paul]; Fonseca, NA[Fonseca, Nuno A.]; Gelpi, JL[Gelpi, Josep Ll]; Getz, G[Getz, Gad]; Gibson, B[Gibson, Bob]; Grossman, RL[Grossman, Robert L.]; Harismendy, O[Harismendy, Olivier]; Heath, AP[Heath, Allison P.]; Heinold, MC[Heinold, Michael C.]; Hess, JM[Hess, Julian M.]; Hofmann, O[Hofmann, Oliver]; Hong, JH[Hong, Jongwhi H.]; Hudson, TJ[Hudson, Thomas J.]; Hutter, B[Hutter, Barbara]; Hutter, CM[Hutter, Carolyn M.]; Hubschmann, D[Huebschmann, Daniel]; Imoto, S[Imoto, Seiya]; Ivkovic, S[Ivkovic, Sinisa]; Jeon, SH[Jeon, Seung-Hyup]; Jiao, W[Jiao, Wei]; Jung, J[Jung, Jongsun]; Kabbe, R[Kabbe, Rolf]; Kahles, A[Kahles, Andre]; Kerssemakers, JNA[Kerssemakers, Jules N. A.]; Kim, HL[Kim, Hyung-Lae]; Kim, H[Kim, Hyunghwan]; Kim, J[Kim, Jihoon]; Kim, Y[Kim, Youngwook]; Kleinheinz, K[Kleinheinz, Kortine]; Koscher, M[Koscher, Michael]; Koures, A[Koures, Antonios]; Kovacevic, M[Kovacevic, Milena]; Lawerenz, C[Lawerenz, Chris]; Leshchiner, I[Leshchiner, Ignaty]; Liu, J[Liu, Jia]; Livitz, D[Livitz, Dimitri]; Mihaiescu, GL[Mihaiescu, George L.]; Mijalkovic, S[Mijalkovic, Sanja]; Lazic, AM[Lazic, Ana Mijalkovic]; Miyano, S[Miyano, Satoru]; Miyoshi, N[Miyoshi, Naoki]; Nahal-Bose, HK[Nahal-Bose, Hardeep K.]; Nakagawa, H[Nakagawa, Hidewaki]; Nastic, M[Nastic, Mia]; Newhouse, SJ[Newhouse, Steven J.]; Nicholson, J[Nicholson, Jonathan]; O'Connor, BD[O'Connor, Brian D.]; Ocana, D[Ocana, David]; Ohi, K[Ohi, Kazuhiro]; Ohno-Machado, L[Ohno-Machado, Lucila]; Omberg, L[Omberg, Larsson]; Ouellette, BFF[Ouellette, B. F. Francis]; Paramasivam, N[Paramasivam, Nagarajan]; Perry, MD[Perry, Marc D.]; Pihl, TD[Pihl, Todd D.]; Prinz, M[Prinz, Manuel]; Puiggros, M[Puiggros, Montserrat]; Radovic, P[Radovic, Petar]; Raine, KM[Raine, Keiran M.]; Rheinbay, E[Rheinbay, Esther]; Rosenberg, M[Rosenberg, Mara]; Royo, R[Royo, Romina]; Ratsch, G[Raetsch, Gunnar]; Saksena, G[Saksena, Gordon]; Schlesner, M[Schlesner, Matthias]; Shorser, SI[Shorser, Solomon, I]; Short, C[Short, Charles]; Sofia, HJ[Sofia, Heidi J.]; Spring, J[Spring, Jonathan]; Stein, LD[Stein, Lincoln D.]; Struck, AJ[Struck, Adam J.]; Tiao, G[Tiao, Grace]; Tijanic, N[Tijanic, Nebojsa]; Torrents, D[Torrents, David]; Van Loo, P[Van Loo, Peter]; Vazquez, M[Vazquez, Miguel]; Vicente, D[Vicente, David]; Wala, JA[Wala, Jeremiah A.]; Wang, ZN[Wang, Zhining]; Weischenfeldt, J[Weischenfeldt, Joachim]; Werner, J[Werner, Johannes]; Williams, A[Williams, Ashley]; Woo, Y[Woo, Youngchoon]; Wright, AJ[Wright, Adam J.]; Xiang, Q[Xiang, Qian]; Yang, LM[Yang, Liming]; Yuen, D[Yuen, Denis]; Yung, CK[Yung, Christina K.]; Zhang, JJ[Zhang, Junjun]
- Issue Date
- Mar-2020
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE BIOTECHNOLOGY, v.38, no.3, pp.288 - 292
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE BIOTECHNOLOGY
- Volume
- 38
- Number
- 3
- Start Page
- 288
- End Page
- 292
- ISSN
- 1087-0156
- Abstract
- Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities. We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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