PRE-Operative ECHOcardiograhy for prevention of cardiovascular events after non-cardiac surgery in intermediate- and high-risk patients: protocol for a low-interventional, mixed-cohort prospective study design (PREOP-ECHO)open access
- Authors
- Kim, EK[Kim, Eun Kyoung]; Choi, HM[Choi, Hong-Mi]; Choi, EY[Choi, Eui-Young]; Lee, HS[Lee, Hye Sun]; Park, G[Park, Goeun]; Han, DW[Han, Dong Woo]; Lee, SE[Lee, Sang-Eun]; Park, CS[Park, Chan Seok]; Hwang, JW[Hwang, Ji-won]; Choi, JH[Choi, Jae Hyuk]; Kim, MN[Kim, Mi-Na]; Kim, HK[Kim, Hyung-Kwan]; Kim, DH[Kim, Dae-Hee]; Shin, SH[Shin, Sung-Hee]; Sohn, IS[Sohn, Il Suk]; Shin, MS[Shin, Mi-Seung]; Na, JO[Na, Jin Oh]; Cho, I[Cho, Iksung]; Lee, SH[Lee, Sun Hwa]; Park, YH[Park, Yong Hyun]; Park, TH[Park, Tae-Ho]; Kim, KH[Kim, Kye Hun]; Cho, GY[Cho, Goo-Young]; Jung, HO[Jung, Hae Ok]; Park, DG[Park, Dae-Gyun]; Hong, JY[Hong, Ji Yeon]; Kang, DH[Kang, Duk-Hyun]
- Issue Date
- 14-Sep-2022
- Publisher
- BMC
- Keywords
- Echocardiography; Noncardiac surgery; Trial design
- Citation
- TRIALS, v.23, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- TRIALS
- Volume
- 23
- Number
- 1
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/99887
- DOI
- 10.1186/s13063-022-06701-2
- ISSN
- 1745-6215
- Abstract
- Background: Cardiac evaluation using transthoracic echocardiography before noncardiac surgery is common in real-world practice. However, evidence supporting preoperative echocardiography is lacking. This study aims to evaluate the additional benefit of preoperative echocardiography in predicting postoperative cardiovascular events (CVE) in noncardiac surgery. Methods: This study is designed as a multicenter, prospective study to assess the utility of preoperative echocardiography in patients undergoing intermediate- or high-risk noncardiac surgery. This trial comprises two studies: (1) a randomized controlled trial (RCT) for patients undergoing intermediate-risk surgery with fewer than three clinical risk factors from the revised cardiac risk index (intermediate-risk group) and (2) a prospective cohort study for patients undergoing intermediate-risk surgery with three or more clinical risk factors, or who undergo high-risk surgery regardless of the number of clinical risk factors (high-risk group). We hypothesize that the use of preoperative echocardiography will reduce postoperative CVEs in patients undergoing intermediate- to high-risk surgery through discovery of and further intervention for unexpected cardiac abnormalities before elective surgery. A total of 2330 and 2184 patients will be enrolled in the two studies. The primary endpoint is a composite of all-cause death; aborted sudden cardiac arrest; type I acute myocardial infarction; clinically diagnosed unstable angina; stress-induced cardiomyopathy; lethal arrhythmia, such as sustained ventricular tachycardia or ventricular fibrillation; and/or newly diagnosed or acutely decompensated heart failure within 30 days after surgery. Discussion: This study will be the first large-scale prospective study examining the benefit of preoperative echocardiography in predicting postoperative CVE. The PREOP-ECHO trial will help doctors identify patients at risk of postoperative CVE using echocardiography and thereby reduce postoperative CVEs.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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