Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy
- Authors
- Dembereldorj, Uuriintuya; Choi, Seon Young; Ganbold, Erdene-Ochir; Song, Nam Woong; Kim, Doseok; Choo, Jaebum; Lee, So Yeong; Kim, Sehun; Joo, Sang-Woo
- Issue Date
- May-2014
- Publisher
- WILEY-BLACKWELL
- Citation
- PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.90, no.3, pp.659 - 666
- Journal Title
- PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Volume
- 90
- Number
- 3
- Start Page
- 659
- End Page
- 666
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/10060
- DOI
- 10.1111/php.12212
- ISSN
- 0031-8655
- Abstract
- Gold nanorod-attached PEGylated graphene-oxide (AuNR-PEG-GO) nanocomposites were tested for a photothermal platform both in vitro and in vivo. Cytotoxicity of AuNR was reduced after encapsulation with PEG-GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB-eliminated AuNR-PEG-GO nanocomposites was examined using dark-field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR-PEG-GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe-lamp light (60Wcm(-2)) for 5min after treatment with the AuNR-PEG-GO nanocomposites for 24h. Cell viability significantly decreased by ~40% when the AuNR-PEG-GO-encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR-PEG-GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HCl-treated AuNR-PEG-GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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