The sweets standing at the borderline between allo- and xenotransplantation
DC Field | Value | Language |
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dc.contributor.author | Jang, Kyoung-Soon | - |
dc.contributor.author | Kim, Yun-Gon | - |
dc.contributor.author | Adhya, Mausumi | - |
dc.contributor.author | Park, Hae-Min | - |
dc.contributor.author | Kim, Byung-Gee | - |
dc.date.available | 2018-05-09T14:07:10Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0908-665X | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/11235 | - |
dc.description.abstract | Animal cells are densely covered with glycoconjugates, such as N-glycan, O-glycan, and glycosphingolipids, which are important for various biological and immunological events at the cell surface and in the extracellular matrix. Endothelial -Gal carbohydrate epitopes (Gal3Gal-R) expressed on porcine tissue or cell surfaces are such glycoconjugates and directly mediate hyperacute immunological rejection in pig-to-human xenotransplantation. Although researchers have been able to develop 1,3-galactosyltransferase (Gal KO) pigs, there remain unclarified non-Gal antigens that prevent xenotransplantation. Based on our expertise in the structural analysis of xenoantigenic carbohydrates, we describe the immunologically significant non-human carbohydrate antigens, including -Gal antigens, analyzed as part of efforts to assess the antigens responsible for hyperacute immunological rejection in pig-to-human xenotransplantation. KO pig glycoprofiles, and of developing adequate pig-to-human glycan databases, is also discussed. | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | XENOTRANSPLANTATION | - |
dc.subject | ABO-BLOOD-GROUP | - |
dc.subject | HANGANUTZIU-DEICHER ANTIGEN | - |
dc.subject | N-GLYCOLYLNEURAMINIC ACID | - |
dc.subject | HUMAN NATURAL ANTIBODIES | - |
dc.subject | MASS-SPECTROMETRY | - |
dc.subject | GAL ANTIBODY | - |
dc.subject | CARDIAC XENOTRANSPLANTATION | - |
dc.subject | ORGAN XENOTRANSPLANTATION | - |
dc.subject | CARBOHYDRATE ANTIGENS | - |
dc.subject | BABOON ANTIBODIES | - |
dc.title | The sweets standing at the borderline between allo- and xenotransplantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/xen.12030 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | XENOTRANSPLANTATION, v.20, no.4, pp.199 - 208 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000322317900001 | - |
dc.identifier.scopusid | 2-s2.0-84881169732 | - |
dc.citation.endPage | 208 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 199 | - |
dc.citation.title | XENOTRANSPLANTATION | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Kim, Yun-Gon | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | glycan database | - |
dc.subject.keywordAuthor | mass spectrometry | - |
dc.subject.keywordAuthor | non-Gal antigen | - |
dc.subject.keywordAuthor | pig glycome | - |
dc.subject.keywordAuthor | xenotransplantation | - |
dc.subject.keywordPlus | ABO-BLOOD-GROUP | - |
dc.subject.keywordPlus | HANGANUTZIU-DEICHER ANTIGEN | - |
dc.subject.keywordPlus | N-GLYCOLYLNEURAMINIC ACID | - |
dc.subject.keywordPlus | HUMAN NATURAL ANTIBODIES | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | GAL ANTIBODY | - |
dc.subject.keywordPlus | CARDIAC XENOTRANSPLANTATION | - |
dc.subject.keywordPlus | ORGAN XENOTRANSPLANTATION | - |
dc.subject.keywordPlus | CARBOHYDRATE ANTIGENS | - |
dc.subject.keywordPlus | BABOON ANTIBODIES | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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