The sweets standing at the borderline between allo- and xenotransplantation
- Authors
- Jang, Kyoung-Soon; Kim, Yun-Gon; Adhya, Mausumi; Park, Hae-Min; Kim, Byung-Gee
- Issue Date
- Jul-2013
- Publisher
- WILEY-BLACKWELL
- Keywords
- glycan database; mass spectrometry; non-Gal antigen; pig glycome; xenotransplantation
- Citation
- XENOTRANSPLANTATION, v.20, no.4, pp.199 - 208
- Journal Title
- XENOTRANSPLANTATION
- Volume
- 20
- Number
- 4
- Start Page
- 199
- End Page
- 208
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/11235
- DOI
- 10.1111/xen.12030
- ISSN
- 0908-665X
- Abstract
- Animal cells are densely covered with glycoconjugates, such as N-glycan, O-glycan, and glycosphingolipids, which are important for various biological and immunological events at the cell surface and in the extracellular matrix. Endothelial -Gal carbohydrate epitopes (Gal3Gal-R) expressed on porcine tissue or cell surfaces are such glycoconjugates and directly mediate hyperacute immunological rejection in pig-to-human xenotransplantation. Although researchers have been able to develop 1,3-galactosyltransferase (Gal KO) pigs, there remain unclarified non-Gal antigens that prevent xenotransplantation. Based on our expertise in the structural analysis of xenoantigenic carbohydrates, we describe the immunologically significant non-human carbohydrate antigens, including -Gal antigens, analyzed as part of efforts to assess the antigens responsible for hyperacute immunological rejection in pig-to-human xenotransplantation. KO pig glycoprofiles, and of developing adequate pig-to-human glycan databases, is also discussed.
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