Characterization of a new ScbR-like gamma-butyrolactone binding regulator (SlbR) in Streptomyces coelicolor
- Authors
- Yang, YH; Song, E; Kim, JN; Lee, BR; Kim, EJ; Park, SH; Kim, WS; Park, HY; Jeon, JM; Rajesh, T; Kim, YG; Kim, BG
- Issue Date
- Oct-2012
- Publisher
- SPRINGER
- Citation
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.96, pp.113 - 121
- Journal Title
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 96
- Start Page
- 113
- End Page
- 121
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/12562
- DOI
- 10.1007/s00253-011-3803-4
- ISSN
- 0175-7598
- Abstract
- gamma-Butyrolactones in Streptomyces are well recognized as bacterial hormones, and they affect secondary metabolism of Streptomyces. gamma-Butyrolactone receptors are considered important regulatory proteins, and various gamma-butyrolactone synthases and receptors have been reported in Streptomyces. Here, we characterized a new regulator, SCO0608, that interacted with SCB1 (gamma-butyrolactone of Streptomyces coelicolor) and bound to the scbR/A and adpA promoters. The SCO0608 protein sequences are not similar to those of any known gamma-butyrolactone binding proteins in Streptomyces such as ScbR from S. coelicolor or ArpA from Streptomyces griseus. Interestingly, SCO0608 functions as a repressor of antibiotic biosynthesis and spore formation in R5 complex media. We showed the existence of another type of gamma-butyrolactone receptor in Streptomyces, and this SCO0608 was named ScbR-like gamma-butyrolactone binding regulator (SlbR) in S. coelicolor.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Department of Chemical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.