Melt crystallization of ibuprofen on surfaces patterned by a Nd : YAG laser
- Authors
- Chung, Jihae; Kim, Byung Jick; Chung, Haseung; Kim, Il Won
- Issue Date
- Jan-2011
- Publisher
- SPRINGER
- Keywords
- Crystallization; Ibuprofen; Dendrite; Laser; Patterning
- Citation
- KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.28, no.1, pp.239 - 245
- Journal Title
- KOREAN JOURNAL OF CHEMICAL ENGINEERING
- Volume
- 28
- Number
- 1
- Start Page
- 239
- End Page
- 245
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/13746
- DOI
- 10.1007/s11814-010-0466-2
- ISSN
- 0256-1115
- Abstract
- Surface-based control of melt crystallization of ibuprofen (IBU) is reported. The substrates in the present study included glass, flat Au, and laser-patterned Au. The IBU crystal morphologies were regulated depending on the surfaces where IBU crystallization was induced, and spherical, sunflower-like, and dendritic morphologies were obtained. Especially, the dendritic morphology of a large surface area was observed on the novel laser-patterned surfaces. Three-dimensionally tortuous Au structures were achieved by a 532 nm Nd : YAG laser, of which Gaussian beam profile was reshaped into a flat-top contour using a custom-designed diffusing system. Also, the effect of poly-e-caprolactone was analyzed as a crystallization modulating additive to fine-tune the IBU crystal morphologies. The IBU crystallization behaviors as well as the laser patterning processes are described as a part of the ongoing efforts to develop a general strategy to utilize heterogeneous nucleation and directional growth to control the crystallization of important organic compounds, such as active pharmaceutical ingredients.
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Collections - College of Engineering > Department of Chemical Engineering > 1. Journal Articles
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