Synergistic OX40 and CD30 signals sustain CD8(+) T cells during antigenic challenge
- Authors
- Bekiaris, Vasileios; Gaspal, Fabrina; Kim, Mi-Yeon; Withers, David R.; Sweet, Clive; Anderson, Graham; Lane, Peter J. L.
- Issue Date
- Aug-2009
- Publisher
- WILEY-BLACKWELL
- Keywords
- CD8; CD30; OX40
- Citation
- EUROPEAN JOURNAL OF IMMUNOLOGY, v.39, no.8, pp.2120 - 2125
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Volume
- 39
- Number
- 8
- Start Page
- 2120
- End Page
- 2125
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/15808
- DOI
- 10.1002/eji.200939424
- ISSN
- 0014-2980
- Abstract
- Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8(+) effectors. Thus, double deficiency in OX40 and CD30 leads to CD8(+) cell loss during expansion after immunization either with OVA or with murine CMV. Following their contraction, OX40- and CD30-deficient CD8(+) T cells persist normally in CMV-infected mice. In contrast, persistence after OVA challenge is dependent on OX40 and CD30. Collectively, our data define the important role of both OX40 and CD30 during CD8(+) T-cell activation, and show that long-term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented.
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