Haplotype Phylogeny of a 200kb Region in the Human Chromosome X Terminal Band (q28)
- Authors
- 김상수
- Issue Date
- 2008
- Publisher
- 한국유전체학회
- Keywords
- haplotype; SNP; phylogeny; haploview; HapMap
- Citation
- Genomics & Informatics, v.6, no.3, pp.130 - 135
- Journal Title
- Genomics & Informatics
- Volume
- 6
- Number
- 3
- Start Page
- 130
- End Page
- 135
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/16974
- ISSN
- 1598-866X
- Abstract
- The haplotypes of a 200 kb region in the human chromosome
X terminal band (q28) were analyzed using the
International HapMap Project PhaseII data, which had
been collected for three analysis panels (YRI, CEU, and
CHB+JPT). When multiple linkage disequilibrium blocks
were encountered for a panel, the neighboring haplotypes
that had crossover rate of 5% or more in the
panel were combined to generate 'haploid' configurations.
This resulted in 8, 7, and 5 'haploid' configurations
for the panels of YRI, CEU, and CHB+JPT,
respectively. The multiple sequence alignment of these
'haploids' was used for the calculation of allele-sharing
distances and the subsequent principal coordinate
analysis. Two 'haploids' in CEU and CHB+JPT were
hypothesized as 'parental' in light of the observations
that the successive recombinants of these haploids can
model two other haploids in CEU and CHB+JPT, and
that their configurations were consistent with those in
YRI. This study demonstrates the utility of haplotype
phylogeny in understanding population evolution.
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