pH-sensitive mesalazine carrier for colon-targeted drug delivery: A two-fold composition of mesalazine with a clay and alginate
- Authors
- Hong, Hye-Jin; Kim, Jiwoong; Suh, Yong Jae; Kim, Daeyoung; Roh, Ki-Min; Kang, Ilmo
- Issue Date
- Nov-2017
- Publisher
- SPRINGER
- Keywords
- targeted drug delivery; side effect; smectite; alginate hydrogel
- Citation
- MACROMOLECULAR RESEARCH, v.25, no.11, pp.1145 - 1152
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 25
- Number
- 11
- Start Page
- 1145
- End Page
- 1152
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39273
- DOI
- 10.1007/s13233-017-5150-5
- ISSN
- 1598-5032
- Abstract
- The release of mesalazine, an anti-inflammatory drug for Crohn's disease, should be deferred while delivering along the gastrointestinal tract to maximize drug absorption in the colon. To that end, we intercalated mesalazine into a clay mineral, montmorillonite (MMT), and we encapsulated the resulting composite inside a pHsensitive polymer, an alginate hydrogel bead. Once intercalated between the microscopic MMT layers, the mesalazine is prevented from dissolution during encapsulation into the alginate beads. As the resulting mesalazine-clay-alginate (MCA) bead is covered with a protective alginate layer, the mesalazine does not dissolve in acidic gastric conditions. In in vitro release tests, the MCA beads exhibited less than 5% mesalazine release in gastric solution, while similar to 20% was released over 7 h in the intestinal condition. Our results demonstrate that the MCA bead is a highly effective, biocompatible means of mesalazine delivery to the colon.
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