Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries
- Authors
- Kim, Taegwan; Ha, Min Woo; Kim, Jonghoon
- Issue Date
- Apr-2022
- Publisher
- MDPI
- Keywords
- natural products; indole; small-molecule library; diversity-oriented synthesis; complexity-to-diversity (Ctd) strategy; biomimetic synthesis
- Citation
- MOLECULES, v.27, no.7
- Journal Title
- MOLECULES
- Volume
- 27
- Number
- 7
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42176
- DOI
- 10.3390/molecules27072171
- ISSN
- 1420-3049
- Abstract
- Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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