Global profiling of RNA-chromatin interactions reveals co-regulatory gene expression networks in Arabidopsis
- Authors
- Li, Lanxia; Luo, Haofei; Lim, Do-Hwan; Han, Lu; Li, Yan; Fu, Xiang-Dong; Qi, Yijun
- Issue Date
- Oct-2021
- Publisher
- NATURE PORTFOLIO
- Citation
- NATURE PLANTS, v.7, no.10, pp.1364 - +
- Journal Title
- NATURE PLANTS
- Volume
- 7
- Number
- 10
- Start Page
- 1364
- End Page
- +
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42367
- DOI
- 10.1038/s41477-021-01004-x
- ISSN
- 2055-026X
- Abstract
- It is increasingly evident that various RNAs can bind chromatin to regulate gene expression and genome organization. Here we adapted a sequencing-based technique to profile RNA-chromatin interactions at a genome-wide scale in Arabidopsis seedlings. We identified more than 10,000 RNA-chromatin interactions mediated by protein-coding RNAs and non-coding RNAs. Cis and intra-chromosomal interactions are mainly mediated by protein-coding RNAs, whereas inter-chromosomal interactions are primarily mediated by non-coding RNAs. Many RNA-chromatin interactions tend to positively correlate with DNA-DNA interactions, suggesting their mutual influence and reinforcement. We further show that some RNA-chromatin interactions undergo alterations in response to biotic and abiotic stresses and that altered RNA-chromatin interactions form co-regulatory networks. Our study provides a global view on RNA-chromatin interactions in Arabidopsis and a rich resource for future investigations of regulatory roles of RNAs in gene expression and genome organization. Genome-wide profiles of RNA-chromatin interactions in Arabidopsis reveal the types of RNAs that mediate cis, intra-chromosomal and inter-chromosomal interactions and suggest the formation of co-regulatory gene expression networks in response to stresses.
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Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
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