Association Between Metabolic Syndrome and Risk of Esophageal Cancer: a Nationwide Population-Based Studyopen access
- Authors
- Lee, Ji Eun; Han, Kyungdo; Yoo, Juhwan; Yeo, Yohwan; Cho, In Young; Cho, Belong; Park, Jin-Ho; Shin, Dong Wook; Cho, Jong Ho; Park, Yong -Moon
- Issue Date
- Dec-2022
- Publisher
- AMER ASSOC CANCER RESEARCH
- Citation
- CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v.31, no.12, pp.2228 - 2236
- Journal Title
- CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Volume
- 31
- Number
- 12
- Start Page
- 2228
- End Page
- 2236
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43778
- DOI
- 10.1158/1055-9965.EPI-22-0703
- ISSN
- 1055-9965
- Abstract
- Background: Metabolic syndrome (MetS) is believed to increase the risk of esophageal cancer. However, most studies have been conducted in Western countries, focusing on esophageal adeno-carcinoma (EAC). We aimed to investigate the association between MetS and risk of esophageal cancer in nationally representative large dataset in Korea, where esophageal squamous cell carcinoma (ESCC) is predominant.Methods: We analyzed the health examinations and claims data from the Korean National Health Insurance Service (NHIS). A total of 6,795,738 subjects who received an NHIS provided health examination in 2009 (index year) were included. Cox proportional hazards models were used to estimate multi -variable adjusted HRs (aHR) and 95% confidence intervals (CI) for the association of MetS and its components (elevated waist circumference, blood pressure, triglycerides, fasting blood glucose, reduced high-density lipoprotein cholesterol) with the risk of esophageal cancer.Results: During a mean (+/- SD) follow-up of 8.2 (+/- 1.1) years, 6,414 cases of esophageal cancer occurred. MetS was associated with an increased risk of esophageal cancer (aHR, 1.11; 95% CI, 1.05- 1.18). Among the components of MetS, elevated waist circumfer-ence (aHR, 1.24; 95% CI, 1.16-1.33), high blood pressure (aHR, 1.29; 95% CI, 1.22-1.37), and fasting blood glucose (aHR, 1.16; 95% CI, 1.11-1.22) were associated with increased risk of esophageal cancer.Conclusions: MetS was associated with an increased risk of esophageal cancer.Impact: Our findings suggest that individuals with MetS may be at increased risk for esophageal cancer, specifically ESCC. Further studies are needed to establish the relationship between MetS and esophageal cancer.
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