Cardiovascular Outcomes according to Comorbidities and Low-Density Lipoprotein Cholesterol in Korean People with Type 2 Diabetes Mellitusopen access
- Authors
- Moon, M.K.; Noh, J.; Rhee, E.-J.; Park, S.H.; Kim, H.C.; Kim, B.J.; Kim, H.J.; Choi, S.; Na, J.O.; Hyun, Y.Y.; Kim, B.J.; Han, K.-D.; Jeong, I.-K.; the Committee of Practice Guideline of Korean Lipid and Atheroscelerosis
- Issue Date
- Jan-2023
- Publisher
- Korean Diabetes Association
- Keywords
- Cardiovascular diseases; Cholesterol; Diabetes mellitus; Dyslipidemias; Korea
- Citation
- Diabetes and Metabolism Journal, v.47, no.1, pp.45 - 58
- Journal Title
- Diabetes and Metabolism Journal
- Volume
- 47
- Number
- 1
- Start Page
- 45
- End Page
- 58
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43792
- DOI
- 10.4093/dmj.2021.0344
- ISSN
- 2233-6079
- Abstract
- Background: There are no clear data to support the cardiovascular (CV) risk categories and low-density lipoprotein cholesterol (LDL-C) treatment goals in Korean people with type 2 diabetes mellitus (T2DM). We evaluated the incidence of cardiovascular disease (CVD) according to comorbidities and suggested LDL-C treatment goals in Korean people with T2DM in nationwide cohort data. Methods: Using the Korean National Health Insurance Service database, 248,002 people aged 30 to 90 years with T2DM who underwent routine health check-ups during 2009 were included. Subjects with previous CVD were excluded from the study. The primary outcome was incident CVD, defined as a composite of myocardial infarction and ischemic stroke during the follow-up period from 2009 to 2018. Results: The mean age of the study participants was 59.6±10.9 years, and median follow-up period was 9.3 years. CVD incidence increased in the order of DM duration of 5 years or more (12.04/1,000 person-years), hypertension (HT) (12.27/1,000 person-years), three or more CV risk factors (14.10/1,000 person-years), and chronic kidney disease (18.28/1,000 person-years). The risk of incident CVD increased linearly from an LDL-C level of ≥70 mg/dL in most patients with T2DM. In T2DM patients without HT or with a DM duration of less than 5 years, the CVD incidence increased from LDL-C level of ≥100 mg/dL. Conclusion: For primary prevention of CVD in Korean adults with T2DM, it can be helpful to lower LDL-C targets when there are chronic kidney disease, HT, a long duration of diabetes mellitus, or three or more CV risk factors. Copyright © 2023 Korean Diabetes Association.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.