Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Studyopen access
- Authors
- Noh, J.; Moon, M.K.; Rhee, E.-J.; Park, S.H.; Kim, H.C.; Kim, B.J.; Kim, H.J.; Choi, S.; Na, J.O.; Hyun, Y.Y.; Kim, B.J.; Han, K.-D.; Jeong, I.-K.; Committee of Practice Guideline of Korean Lipid and Atherosclerosis
- Issue Date
- Jan-2023
- Publisher
- Korean Diabetes Association
- Keywords
- Cardiovascular diseases; Cholesterol; Korea; LDL
- Citation
- Diabetes and Metabolism Journal, v.47, no.1, pp.59 - 71
- Journal Title
- Diabetes and Metabolism Journal
- Volume
- 47
- Number
- 1
- Start Page
- 59
- End Page
- 71
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43793
- DOI
- 10.4093/dmj.2021.0320
- ISSN
- 2233-6079
- Abstract
- Background: To validate the treatment target of low-density lipoprotein cholesterol (LDL-C) level according to the cardiovascular disease (CVD) risk which was recommended by Korean dyslipidemia guideline. Methods: We used the Korean National Health Insurance Service database which included 3,958,048 people aged 20 to 89 years who underwent regular health screening. The primary outcome was incident CVD, defined as a composite of myocardial infarction and stroke during the follow-up period from 2009 to 2018. Results: The risk of CVD increased from LDL-C level of 70 mg/dL in very high-risk and high-risk groups and from 130 mg/dL in moderate-risk and low-risk groups. Adjusted hazard ratios (HRs) of LDL-C ranges 70-99, 100-129, 130-159, 160-189, and ≥190 mg/dL were 1.20 (95% confidence interval [CI], 1.08-1.33), 1.27 (1.15-1.42), 1.39 (1.23-1.56), 1.69 (1.45-1.96), and 1.84 (1.49-2.27) in very high-risk group, and 1.07 (1.02-1.13), 1.16 (1.10-1.21), 1.29 (1.22-1.36), 1.45 (1.36-1.55), and 1.73 (1.58-1.90) in high-risk group. Adjusted HRs (95% CI) of LDL-C ranges 130-159, 160-189, and ≥190 mg/dL were 1.15 (1.11-1.20), 1.28 (1.22-1.34), and 1.45 (1.36-1.54) in moderate-risk group and 1.07 (1.02-1.13), 1.20 (1.13-1.26), and 1.47 (1.37-1.57) in low-risk group. Conclusion: We confirmed the incidence of CVD was increased in higher LDL-C range. The risk of CVD increased from ≥70 mg/dL of LDL-C in very high-risk and high-risk groups, and from ≥130 mg/dL of LDL-C in moderate-risk and low-risk groups in Korean adults. Copyright © 2023 Korean Diabetes Association.
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