MicroRNA miR-263b-5p Regulates Developmental Growth and Cell Association by Suppressing Laminin A in Drosophila
DC Field | Value | Language |
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dc.contributor.author | Kim, Chae Jeong | - |
dc.contributor.author | Kim, Hyun Ho | - |
dc.contributor.author | Kim, Hee Kyung | - |
dc.contributor.author | Lee, Sojeong | - |
dc.contributor.author | Jang, Daegyu | - |
dc.contributor.author | Kim, Chanhyeok | - |
dc.contributor.author | Lim, Do-Hwan | - |
dc.date.accessioned | 2023-09-15T02:40:05Z | - |
dc.date.available | 2023-09-15T02:40:05Z | - |
dc.date.created | 2023-09-15 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2079-7737 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44276 | - |
dc.description.abstract | Basement membranes (BMs) play important roles under various physiological conditions in animals, including ecdysozoans. During development, BMs undergo alterations through diverse intrinsic and extrinsic regulatory mechanisms; however, the full complement of pathways controlling these changes remain unclear. Here, we found that fat body-overexpression of Drosophila miR-263b, which is highly expressed during the larval-to-pupal transition, resulted in a decrease in the overall size of the larval fat body, and ultimately, in a severe growth defect accompanied by a reduction in cell proliferation and cell size. Interestingly, we further observed that a large proportion of the larval fat body cells were prematurely disassociated from each other. Moreover, we present evidence that miR-263b-5p suppresses the main component of BMs, Laminin A (LanA). Through experiments using RNA interference (RNAi) of LanA, we found that its depletion phenocopied the effects in miR-263b-overexpressing flies. Overall, our findings suggest a potential role for miR-263b in developmental growth and cell association by suppressing LanA expression in the Drosophila fat body. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | BIOLOGY-BASEL | - |
dc.title | MicroRNA miR-263b-5p Regulates Developmental Growth and Cell Association by Suppressing Laminin A in Drosophila | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/biology12081096 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOLOGY-BASEL, v.12, no.8 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001055457100001 | - |
dc.identifier.scopusid | 2-s2.0-85168973886 | - |
dc.citation.number | 8 | - |
dc.citation.title | BIOLOGY-BASEL | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Lim, Do-Hwan | - |
dc.identifier.url | https://www.mdpi.com/2079-7737/12/8/1096 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | miR-263b | - |
dc.subject.keywordAuthor | Laminin A | - |
dc.subject.keywordAuthor | extracellular matrix | - |
dc.subject.keywordAuthor | basement membrane | - |
dc.subject.keywordAuthor | tissue remodeling | - |
dc.subject.keywordAuthor | fat body | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | DISTINCT ROLES | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | SIZE | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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