MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophilaopen access
- Authors
- Kim, Hee Kyung; Kim, Chae Jeong; Jang, Daegyu; Lim, Do-Hwan
- Issue Date
- Aug-2023
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- Drosophila; found-in-neurons; growth; JAK/STAT signaling; JNK signaling; melanotic mass; miR-274
- Citation
- Insects, v.14, no.8
- Journal Title
- Insects
- Volume
- 14
- Number
- 8
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44281
- DOI
- 10.3390/insects14080709
- ISSN
- 2075-4450
- Abstract
- The hematopoietic system plays a crucial role in immune defense response and normal development, and it is regulated by various factors from other tissues. The dysregulation of hematopoiesis is associated with melanotic mass formation; however, the molecular mechanisms underlying this process are poorly understood. Here, we observed that the overexpression of miR-274 in the fat body resulted in the formation of melanotic masses. Moreover, abnormal activation of the JNK and JAK/STAT signaling pathways was linked to these consequences. In addition to this defect, miR-274 overexpression in the larval fat body decreased the total tissue size, leading to a reduction in body weight. miR-274-5p was found to directly suppress the expression of found-in-neurons (fne), which encodes an RNA-binding protein. Similar to the effects of miR-274 overexpression, fne depletion led to melanotic mass formation and growth reduction. Collectively, miR-274 plays a regulatory role in the fne–JNK signaling axis in melanotic mass formation and growth control. © 2023 by the authors.
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