Association between the accumulation of elevated serum ?-glutamyltransferase level and risk of atrial fibrillation: a nationwide cohort studyopen access
- Authors
- Jeon, Won Kyeong; Lee, So-Ryoung; Han, Kyung-Do; Choi, Eue-Keun; Oh, Seil; Lip, Gregory Y. H.
- Issue Date
- Aug-2023
- Publisher
- NATURE PORTFOLIO
- Citation
- SCIENTIFIC REPORTS, v.13, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 13
- Number
- 1
- URI
- https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44548
- DOI
- 10.1038/s41598-023-40689-2
- ISSN
- 2045-2322
- Abstract
- Atrial fibrillation (AF) is the most common cardiac arrhythmia. The association between AF and & gamma;-Glutamyltransferase (GGT) was not fully established. This study demonstrated the independent association of cumulative GGT score and AF incidence with the dose-response relationship. Using the Korean National Health Insurance Corporation database, adult subjects who had 4 consecutive annual health examinations from 2009 to 2012 were enrolled. A cumulative GGT score was calculated as the cumulative number of the highest GGT quartile amongst four examinations (0-4 times). A multivariable Cox proportional hazards regression analysis was performed. Among a total of 3,500,847 people included, AF was developed in 27,752 people (0.793%) during a median of 8.0 years of follow up. The incidence rate of AF and adjusted hazard ratio were increased by a stepwise manner in the higher quartile group and cumulative GGT score group. In subgroup analysis, this trend was more prominent in the elderly, people without hypertension, non-obese people, and people without any four comorbidities (diabetes mellitus, hypertension, dyslipidemia, and obesity). Our results suggest multiple accumulation of elevated GGT levels in health examination might be a useful marker for risk stratification of AF development, especially in the elderly and healthy population.
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