Assessing the cost-effectiveness of annual COVID-19 booster vaccination in South Korea using a transmission dynamic modelopen access
- Authors
- Choi, Wongyeong; Shim, Eunha
- Issue Date
- Nov-2023
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- COVID-19; coronavirus disease; COVID-19 vaccine; annual vaccination; South Korea; cost-effectiveness; mathematical modeling; SARS-CoV-2
- Citation
- FRONTIERS IN PUBLIC HEALTH, v.11
- Journal Title
- FRONTIERS IN PUBLIC HEALTH
- Volume
- 11
- URI
- https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/48975
- DOI
- 10.3389/fpubh.2023.1280412
- ISSN
- 2296-2565
2296-2565
- Abstract
- IntroductionWe evaluated the cost-effectiveness of South Korea's planned annual coronavirus disease 2019 (COVID-19) booster campaign scheduled for October 2023.Materials and methodsAn age-structured mathematical model was used to analyze the public impacts and cost-effectiveness of vaccination across three vaccination strategies: uniform allocation and prioritizing those over 65 or those over 50 years old. We calculated the incremental cost per quality-adjusted life year (QALY) from both healthcare and societal perspectives. The maximum vaccine cost for cost-effectiveness was also identified.ResultsOur analysis highlights the cost-effectiveness of South Korea's annual COVID-19 vaccination program in mitigating health and economic impacts. The most cost-effective strategy is uniform vaccine allocation, offering the lowest incremental cost-effectiveness ratio (ICER) at US$ 25,787/QALY. However, with a relatively high attack rate, the strategy prioritizing individuals over 65 years emerges as more cost-effective, lowering the ICER to US$ 13,785/QALY. Prioritizing those over 50 was less cost-effective. All strategies were cost-saving from a societal perspective, with cost-effectiveness being more sensitive to vaccine price than to its effectiveness.DiscussionOur results imply a potential strategy shift in current vaccination plan, with uniform vaccine distribution being more cost-effective than prioritizing older adults. Early estimation of viral transmissibility and vaccine effectiveness is crucial in determining the most cost-effective vaccine allocation approach.
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