Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A PopulationBased Matched Cohort Studyopen access
- Authors
- Kim, Taehee; Choi, Hayoung; Kim, Sang Hyuk; Yang, Bumhee; Han, Kyungdo; Jung, Jin-Hyung; Kim, Bo-Guen; Park, Dong Won; Moon, Ji Yong; Kim, Sang-Heon; Kim, Tae-Hyung; Yoon, Ho Joo; Shin, Dong Wook; Lee, Hyun
- Issue Date
- Mar-2024
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Pulmonary Tuberculosis; Chronic Obstructive Pulmonary Disease; Hospitalization; Observational Study
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.39, no.11
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 39
- Number
- 11
- URI
- https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49457
- DOI
- 10.3346/jkms.2024.39.e105
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54-1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81-2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17-2.92). Conclusion: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
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