ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
- Authors
- Song, Yu Seok; Balcos, Marie Carmel; Yun, Hye-Young; Baek, Kwang Jin; Kwon, Nyoun Soo; Kim, Myo-Kyoung; Kim, Dong-Seok
- Issue Date
- Jan-2015
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- ERK; Fucoidan; Melanogenesis; MITF; Tyrosinase
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.19, no.1, pp 29 - 34
- Pages
- 6
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 19
- Number
- 1
- Start Page
- 29
- End Page
- 34
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10024
- DOI
- 10.4196/kjpp.2015.19.1.29
- ISSN
- 1226-4512
2093-3827
- Abstract
- Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigrnentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation.
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