Utilization of the respiratory virus multiplex reverse transcription-polymerase chain reaction test for adult patients at a Korean tertiary care center
- Authors
- Ahn, Mi Young; Choi, Seong-Ho; Chung, Ji -Won; Kim, Hye Ryoun
- Issue Date
- Jan-2015
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Viruses; Respiratory tract infections; Multiplex polymerase chain reaction
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.30, no.1, pp 96 - 103
- Pages
- 8
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 30
- Number
- 1
- Start Page
- 96
- End Page
- 103
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10027
- DOI
- 10.3904/kjim.2015.30.1.96
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: Respiratory viruses (RVs) are considered to be important respiratory pathogens in adult patients, and the multiplex reverse transcription-polymerase chain reaction (RT-PCR) test is used frequently in adult patients with respiratory infections. However, clinical data regarding utilization of the multiplex RT-PCR test for RVs are lacking. Methods: We investigated the utilization of the multiplex RT-PCR test for RVs at Chung-Ang University Hospital in Seoul, Korea, between January 2012 and April 2013. Results: During the study period, the multiplex RT-PCR test was performed for 291 adult patients. The test frequency was 4.9% of rapid influenza antigen detection tests and 0.8% of respiratory bacterial culture studies. A turnaround time of < 48 hours was observed in 25.9% of positive tests. Most of the tests were performed for admitted patients (97.9%) with a community-acquired infection (84.2%) during the flu season (82.5%). RVs were detected in 81 of 291 cases (27.8%). The RV positivity rates for community- and hospital-acquired infections did not differ (28.6% vs. 23.9%, p = 0.52). Of 166 patients with pneumonia, 44 (26.5%) had a viral infection. Among the patients with RV-associated pneumonia, an RV other than influenza was detected in 20 patients (45.4%). Conclusions: The multiplex RT-PCR test for RVs was infrequently performed at a tertiary care center, and the test results were often reported late. The test was most often performed for admitted adult patients with community-acquired infections during the flu season. The utilization of multiplex RT-PCR testing for RVs in current clinical practice should be improved.
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