The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean populationopen access
- Authors
- Choi, Se Young; Kim, Hae Jong; Cheong, Hyun Sub; Myung, Soon Chul
- Issue Date
- Jan-2015
- Publisher
- KOREAN UROLOGICAL ASSOC
- Keywords
- Genetic polymorphism; Human SRD5A2 protein; Prostatic neoplasms
- Citation
- KOREAN JOURNAL OF UROLOGY, v.56, no.1, pp 19 - 29
- Pages
- 11
- Journal Title
- KOREAN JOURNAL OF UROLOGY
- Volume
- 56
- Number
- 1
- Start Page
- 19
- End Page
- 29
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/10067
- DOI
- 10.4111/kju.2015.56.1.19
- ISSN
- 2005-6737
2005-6745
- Abstract
- Purpose: Steroid 5-alpha reductase type 2 (SRD5A2) modifies testosterone to dihydrotestosterone (DHT) in the prostate. Single-nucleotide polymorphisms (SNPs) of the SRD5A2 gene might affect DHT. We sought to understand the relationship of SRD5A2 SNPs to prostate cancer in the Korean population. Materials and Methods: Twenty-six common SNPs in the SRD5A2 gene were assessed in 272 prostate cancer cases and 173 controls. Single-locus analyses were conducted by using conditional logistic regression. Additionally, we performed a haplotype analysis for the SRD5A2 SNPs tested. Results: Among the 20 SNPs and 4 haplotypes, there were no statistically significant results in the prostate cancer patients and the controls. In the logistic analysis of SRD5A2 polymorphisms with prostate-specific antigen (PSA) criteria, two SNPs (rs508562, rs11675297) and haplotype 1 displayed significant results (odds ratio [OR], 1.76; p=0.05; OR, 1.88-2.02; p=0.01-0.04; OR, 0.59; p=0.02, respectively). rs508562, rs11675297, rs2208532, and haplotype 1 (OR, 1.49; p=0.05; OR, 2.02; p=0.05; OR, 2.01; p=0.04; OR, 0.56-0.64, p=0.03-0.04, respectively) had significant associations with Gleason score. rs508562, rs11675297, and haplotype 1 (OR, 1.41-2.34; p=0.004-0.05; OR, 1.74-1.82; p=0.03-0.05; OR, 0.42-0.67; p=0.0005-0.03, respectively) were significantly associated with clinical stage. Conclusions: We conclude that there was no significant association between SRD5A2 SNPs and the risk of prostate cancer in the Korean population. However, we found that some SNPs and 1 haplotype influenced PSA level, Gleason score, and clinical stage.
- Files in This Item
-
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.